Improvement of the synthesis of dicain

…, AA Krivoruchko, SV Nekrasov, BV Passet…

Index: Bulat, A. D.; Krivoruchko, A. A.; Nekrasov, S. V.; Passet, B. V.; Samarenko, V. Ya.; Foshkin, V. G. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 6 p. 449 - 451 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 6 p. 716 - 719

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Abstract

The overall yield of I via this scheme in many respects is determined by the transesterificatlon step (the transformation VII § In [4] it is pointed out that this reaction proceeds in 80% yield; however, the qualitative and quantitative indexes of VIII, the method used to purify it, and the results of elementary analysis are not presented. We reproduced the synthesis of VIII from VII by the method in [4] and analyzed the product by gas-liquid ...