Convolutamydine A and synthetic analogues have antinociceptive properties in mice

…, BV Silva, FA Violante, AC Pinto, PD Fernandes

Index: Figueiredo, Gabriela S.M.; Zardo, Renata S.; Silva, Barbara V.; Violante, Flavio A.; Pinto, Angelo C.; Fernandes, Patricia D. Pharmacology Biochemistry and Behavior, 2013 , vol. 103, # 3 p. 431 - 439

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Citation Number: 16

Abstract

Convolutamydine A, an oxindole that originated from a marine bryozoan, has several biological effects. In this study, we aimed to investigate the antinociceptive effects of convolutamydine A and two new synthetic analogues. Convolutamydine A and the two analogues were given orally to assess their ability to induce antinociceptive effects. Formalin- induced licking response, acetic acid-induced contortions, and hot plate models were ...