Total synthesis of apoptolidin: construction of enantiomerically pure fragments

…, P Guntupalli, D Hepworth, K Sugita

Index: Wanner, Martin J.; Koomen, Gerrit-Jan; Pandit, Upendra K. Heterocycles, 1982 , vol. 17, p. 59 - 62

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Citation Number: 109

Abstract

... Volume: Page: ... DIBAL-H (2.5 equiv), toluene, −78 °C, 2 h, 89%; (i) TPAP (0.05 equiv), NMO (6.0 equiv), 4Å MS, CH 2 Cl 2 , 25 °C, 30 min; (j) NaH (5.0 ... EtO) 2 P( O)CH(CH 3 )CO 2 Me (6.0 equiv), THF, 0 → 25 °C, 1 h, E:Z >10:1, 95% over two steps; (k) TBAF (4.0 ...