Bioorganic & medicinal chemistry letters

Synthesis and antibacterial activity of novel fluoroquinolones containing substituted piperidines

Z Dang, Y Yang, R Ji, S Zhang

Index: Dang, Zhao; Yang, Yushe; Ji, Ruyun; Zhang, Shuhua Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4523 - 4526

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Citation Number: 58

Abstract

The design and synthesis of new fluoroquinolone antibacterial agents having substituted piperidine rings at the C-7 position are described. Most of the new compounds demonstrated high in vitro antibacterial activity. Several of them exhibited significant activities against Gram-positive organisms, which were more potent than those of gemifloxacin, Linezolid, and vancomycin.

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