The Journal of Organic Chemistry

Antineoplastic Agents. VI. Mannich Base Nitrogen Mustards (Part B) 1-3

GR Pettit, JA Settepani

Index: Pettit,G.R.; Settepani,J.A. Journal of Organic Chemistry, 1962 , vol. 27, p. 1714 - 1717

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Citation Number: 10

Abstract

A Mannich-type reaction involving bis (Bchloroethyl) amine, formaldehyde, and several amides has been investigated. Bis (2-chloroethy1) amine waa shown to condense in ethanol-formalin solution with phthalimide, saccharin, isatin, and isatin thiosemicarbazone to yield (5149%) the corresponding nitrogen mustard Mannich bases 11, IV, and VI. The reaction was found to follow other courses under acidic conditions. Formation of N- ...