Ribonucleosides of 3-amino-and 3, 5-diaminopyrazole-4-carboxylic acid and their open-chain analogues: Synthesis and reactions

…, A Holý, M Masojídková

Index: Spassova, Maria K.; Holy, Antonin; Masojidkova, Milena Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 7 p. 1512 - 1531

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Citation Number: 6

Abstract

Abstract Bis (trimethylsilyl) derivative of ethyl 3-aminopyrazole-4-carboxylate (VI) and tris (trimethylsilyl) derivative of ethyl 3, 5-diaminopyrazole-4-carboxylate (VII) on reaction with 2, 3, 5-tri-O-benzoyl-D-ribofuranolyl chloride and subsequent debenzoylation afforded the respective β-D-ribofuranosyl derivatives VIIIa and Xa. Their alkaline hydrolysis led to 1-(β-D- ribofuranosyl)-3-aminopyrazole-4-carboxylic acid (VIIIc) and 1-(β-D-ribofuranosyl)-3, 5- ...