Vinylogous carbinolamine tumor inhibitors. 21. Synthesis, chemical reactivity, and antileukemic activity of 5-substituted 6, 7-bis (hydroxymethyl) pyrrolo [1, 2-c] thiazole …

WK Anderson, RH Mach

Index: Anderson, Wayne K.; Mach, Robert H. Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2109 - 2115

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Citation Number: 2

Abstract

A series of bis (N-methylcarbamate) and bis [N-(2-propy1) carbamatel derivatives of 5- substituted 6, 7-bis (hydroxy-methyl) pyrrolo [l, 2-c] thiazoles was prepared. The compounds were tested for activity in vivo against P388 lymphocytic leukemia, and the chemical reactivities of the compounds were compared by using the model nucleophile 4-(4- nitrobenzy1) pyridine (NBP). The 5-(3, 4-dichlorophenyl)-substituted biscarbamates 6b, ...