A Novel Synthesis of 5, 6??Dihydroindazolo [3, 2??a] isoquinolines and Their Relative Compounds via Tin (II) Chloride Dihydrate as Reducing Agent

CY Kuo, MJ Wu

Index: Kuo, Chen-Yuan; Wu, Ming-Jung Journal of the Chinese Chemical Society, 2005 , vol. 52, # 5 p. 965 - 974

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Citation Number: 6

Abstract

A series of 1-(2-nitrophenyl)-3,4-dihydroisoquinolines were reduced under very mild reaction conditions in the presence of Tin(II) chloride dihydrate (SnCl2Ě2H2O) to give 5,6-dihydroindazolo[3,2-a]isoquinolines 4a-h. A mechanism for this reaction is proposed. ... The synthesis of isoquinolines and their derivatives has received much attention1-5 due to their widespread occur- rence in nature6-8 and broad biological activities.9-15 The pyr- ...