Highly enantioselective reduction of the C–C double bond of N-phenyl-2-methyl-and N-phenyl-2, 3-dimethyl-maleimides by fungal strains

MA Sortino, V Cechinel Filho, SA Zacchino

Index: Sortino, Maximiliano A.; Filho, Valdir Cechinel; Zacchino, Susana A. Tetrahedron Asymmetry, 2009 , vol. 20, # 10 p. 1106 - 1108

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Citation Number: 5

Abstract

The CC double bond of non-substituted and substituted maleimides were hydrogenated to the corresponding succinimides by fungal strains. 2-and 2, 3-methylated-phenyl-maleimides were enantioselectively reduced to (R)-N-phenyl-3-methylsuccinimide and to trans-(R, R)-N- phenyl-2, 3-dimethylsuccinimide respectively by Aspergillus niger, A. flavus and A. fumigatus (conversion 96 to 99%), Fusarium graminearum and Penicillium sp (conversion: ...