Easy access to 5-(E)-alkynylidene tetrahydro-2 furanones by a palladium catalyzed process

D Bouyssi, J Gore, G Balme

Index: Bouyssi, Didier; Gore, Jacques; Balme, Genevieve Tetrahedron Letters, 1992 , vol. 33, # 20 p. 2811 - 2814

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Citation Number: 51

Abstract

Abstract Biologically active ynenol lactones 1 are stereospecifically obtained when acetylenic carboxylates are reacted with 1-bromo 1-alkynes in the presence of a palladium (O)-phosphine complex. The reaction is effective only with the potassium carboxylate and the nature of the phosphine is essential for the cyclisation process.