Molecules

Synthesis and antiproliferative activity of some novel triazole derivatives from dehydroabietic acid

…, V Verdugo, C Theoduloz, G Schmeda-Hirschmann

Index: Pertino, Mariano Walter; Verdugo, Valery; Theoduloz, Cristina; Schmeda-Hirschmann, Guillermo Molecules, 2014 , vol. 19, # 2 p. 2523 - 2535

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Citation Number: 13

Abstract

Abstract: Dehydroabietic acid (DHA) is a naturally occurring diterpene with different and relevant biological activities. Previous studies have shown that some DHA derivatives display antiproliferative activity. However, the reported compounds did not include triazole derivatives. Starting from DHA (8, 11, 13-abietatrien-18-oic acid), and its alcohol dehydroabietinol (8, 11, 13-abietatrien-18-ol), four alkyl esters were prepared. The alkyl ...

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