The Complete Stereochemistry of the Enzymatic Dehydration of 4??Hydroxybutyryl Coenzyme A to Crotonyl Coenzyme A

P Friedrich, DJ Darley, BT Golding…

Index: Friedrich, Peter; Darley, Daniel J.; Golding, Bernard T.; Buckel, Wolfgang Angewandte Chemie - International Edition, 2008 , vol. 47, # 17 p. 3254 - 3257

Full Text: HTML

Citation Number: 17

Abstract

4-Hydroxybutyryl coenzymeA (4-hydroxybutyryl-CoA, 1, Scheme 1) contains three diastereotopic methylene groups which either lose or gain a hydrogen atom during the reversible dehydration to crotonyl-CoA (but-2-enoyl-CoA, 2). 4-Hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum, which catalyzes this intriguing g elimination of water,[1] has been shown to be also involved in the recently discovered fifth CO2 ...