European journal of medicinal chemistry

Solvent-free, microwave assisted Knoevenagel condensation of novel 2, 5-disubstituted indole analogues and their biological evaluation

JS Biradar, BS Sasidhar

Index: Biradar; Sasidhar European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 6112 - 6118

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Citation Number: 40

Abstract

A rapid, efficient and environmental benign methodology for the preparation of 2, 5- disubstituted indole analogues is developed. 2, 5-Disubstituted indole-3-carboxaldehydes (1a–c) undergo Knoevenagel condensation with barbiturates (2 &4), thiazolidine-2, 4-dione (6) and 3-methyl-1H-pyrazol-5 (4H)-one (8) in solvent-free, NH4OAc catalyzed, microwave assisted reaction. Structures of the products thus obtained were confirmed by their mp, ...