Journal of medicinal chemistry

Synthesis and characterization of N2-(pn-butylphenyl)-2'-deoxyguanosine and its 5'-triphosphate and their inhibition of HeLa DNA polymerase. alpha.

GE Wright, LW Dudycz

Index: Wright, George E.; Dudycz, Lech W. Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 175 - 181

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Citation Number: 89

Abstract

Department of Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605. Received July 5, 1983~-@-n-Butylphenyl)-2'-deoxyguanosine (BuPdG) and its 5'-triphosphate (BuPdGTP), expected to be inhibitors of eukaryotic DNA polymerase CY, have been synthesized. BuPdG was synthesized by two methods and characterized by lH NMR and by chemical relation to guanosine. Direct synthesis ...

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