Synthesis of N-(carbonylamino)-1, 2, 3, 6-tetrahydropyridines with analgesic, antiinflammatory, and hyperglycemic activity

JM Yeung, LA Corleto, EE Knaus

Index: Yeung, Jupita M.; Corleto, Linda A.; Knaus, Edward E. Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 191 - 195

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Citation Number: 15

Abstract

-N la, R= phenyl IC, R= 3-pyridyl d, R= 4-pyridyl b, R= 2-pyridyl imin0) pyridinium ylides, which exhibited significant an-algesic, antiinflammatory, and hyperglycemic activities. 2 It was therefore of interest to extend this series to deter-mine what effect incorporation of other ring systems and functionality would have on pharmacological activity. We now describe the synthesis and analgesic, antiinflammatory, and hyperglycemic activities of structurally ...