Sequential Combination of Ruthenium??, Base??, and Gold??Catalysis–A New Approach to the Synthesis of Medicinally Important Heterocycles

DB Ramachary, VV Narayana

Index: Ramachary, Dhevalapally B.; Narayana, Vidadala V. European Journal of Organic Chemistry, 2011 , # 19 p. 3514 - 3522

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Citation Number: 12

Abstract

Abstract A general approach to the high-yielding synthesis of medicinally important heterocycles was achieved through the sequential combination of ring-closing metathesis, base-induced ring opening (BIRO), hydroamination, and a Diels–Alder reaction of functionalized allyl-(2-allylphenyl) amines in the presence of a catalytic amount of Grubbs' second-generation catalyst, base (tBuOK), and [AuCl (PPh 3)]/AgOTf. Herein, we also ...