CNS depressant activity of pyrimidylthiazolidones and their selective inhibition of NAD??dependent pyruvate oxidation

…, SK Chaudhary, AK Chaturvedi…

Index: Chaudhary; Parmar; Chaturvedi; Sastry Journal of Pharmaceutical Sciences, 1976 , vol. 65, # 3 p. 443 - 446

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Citation Number: 53

Abstract

Abstract Several 1-aryl-3-(2-pyrimidyl) thiocarbamides and their corresponding cyclized 2- arylimino-3-(2-pyrimidyl) thiazolid-4-ones were synthesized and characterized by their sharp melting points and elemental analyses. These thiocarbamides and thiazolidones possessed anticonvulsant activity against pentylenetetrazol-induced convulsions and potentiated pentobarbital-induced hypnosis in mice. Most of these thiocarbamides and thiazolidones ...