Synthesis of isomeric series of aryltetrahydrobenz??isoxazoles and arylcyclopentisoxazoles

E Fos, L Borràs, M Gasull, D Mauleón…

Index: Fos, Empar; Borras, Liset; Gasull, Maria; Mauleon, David; Carganico Germano Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 1 p. 203 - 208

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Citation Number: 8

Abstract

Abstract Four series of potential PAF-antagonists in which the isoxazole nucleus is condensed with a polyhydrogenated five-or six-carbon ring were prepared. The synthesis of the compounds 3-aryl-4, 5, 6, 7-tetrahydrobenz [c] isoxazoles 1, 3-arylcyclopent [c] isoxazoles 2, 3-aryl-4, 5, 6, 7-tetrahydrobenz [d] isoxazoles 3, and 3-arylcyclopent [d] isoxazoles 4, required an extensive optimization and comparison of the methods available ...

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