Efficient Method for Selective Introduction of Substituents as C (5) of Isoleucine and Other α-Amino Acids

LR Reddy, BVS Reddy, EJ Corey

Index: Reddy, Leleti Rajender; Reddy, B. V. Subba; Corey Organic Letters, 2006 , vol. 8, # 13 p. 2819 - 2821

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Citation Number: 25

Abstract

This paper describes an efficient methodology for the synthesis of useful chiral substances from the readily available α-amino acids isoleucine, norleucine, and leucine. Although isoleucine is unique among the 20 genetically coded amino acids in having both a branched carbon chain and two stereocenters, it has not been used as a platform for generating more complex α-amino acids by the selective introduction of new substituents. We envisaged that such α-amino ...