Tetrahedron Letters

Efficient synthesis of β-amino bromides

AS Nagle, RN Salvatore, BD Chong, KW Jung

Index: Nagle, Advait S.; Salvatore, Ralph N.; Chong, Byong-Don; Woon Jung, Kyung Tetrahedron Letters, 2000 , vol. 41, # 17 p. 3011 - 3014

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Citation Number: 45

Abstract

β-Aminoalcohols were smoothly converted to β-amino bromides using thionyl bromide and DMF, which were easily isolated without any further purification. Participation by the β-amino group in brominations not only enhanced reaction rates but also promoted stereo-and regioselectivities.