Synthesis of new derivatives of pyrazolone and nicotinic acid and study of their effect on cytochrome P-450 activity

…, IV Voznyi, NP Stepanova, AE Khovanskikh

Index: Shemarova; Maizel; Voznyi; Stepanova; Khovanskikh Pharmaceutical Chemistry Journal, 2000 , vol. 34, # 10 p. 530 - 532

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Citation Number: 10

Abstract

At present, medicine employs preparations capable of inhibiting enzymes involved in the metabolism of xenobiotics; drugs of this type include, for example, iproniazid, imipramine, chlorcyclizine, and glutethimide [1, 2]. The purpose of this work was to synthesize Schiff bases from 4-aminopyrazolones, to synthesize hydrazones from nicotinic acid hydrazides and N-benzoyl-b-alanine, and to study the effect of the synthesized compounds on the ...