Synthesis of novel building blocks of benzosuberone bearing coumarin moieties and their evaluation as potential anticancer agents

…, L Nagarapu, CG Kumar, S Pombala, B Sridhar

Index: Yadagiri, Bandi; Holagunda, Uma Devi; Bantu, Rajashaker; Nagarapu, Lingaiah; Kumar, C. Ganesh; Pombala, Sujitha; Sridhar European Journal of Medicinal Chemistry, 2014 , vol. 79, p. 260 - 265

Full Text: HTML

Citation Number: 16

Abstract

Abstract A series of novel benzosuberone bearing coumarin moieties 5a–c have been synthesized and their structures were determined by analytical and spectral (FT-IR, 1 H NMR, 13 C NMR, HRMS) studies. The newly synthesized compounds were evaluated for their cytotoxicity against four human cancer cell lines, A549 (Human alveolar adenocarcinoma cell line), HeLa (Human cervical cancer cell line), MDA-MB-231 (Human ...