Journal of Fluorine Chemistry

Improved synthesis of d, l-fluorocitric acid

R Vardanyan, VK Kumirov, VJ Hruby

Index: Vardanyan, Ruben; Kumirov, Vlad K.; Hruby, Victor J. Journal of Fluorine Chemistry, 2011 , vol. 132, # 11 p. 920 - 924

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Citation Number: 3

Abstract

We propose a decagram synthesis of commercially unavailable fluorocitric acid. The synthesis begins with benzyl fluoroacetate, which is converted to dibenzyl 2-fluoro-3- oxosuccinate, followed by condensation with malonic acid or its monobenzyl ester and subsequent hydrogenolysis.