Rh-catalyzed intramolecular aromatic C–H insertion of α-diazo β-ketoesters: synthesis of 4-carbonyl chroman derivatives

X Zhang, M Lei, YN Zhang, LH Hu

Index: Zhang, Xiaolin; Lei, Mei; Zhang, Yi-Nan; Hu, Li-Hong Tetrahedron, 2014 , vol. 70, # 21 p. 3400 - 3406

Full Text: HTML

Citation Number: 3

Abstract

Abstract A Rh-catalyzed intramolecular aromatic C–H insertion of α-diazo β-ketoesters was developed. This protocol offers a practical strategy for the synthesis of 4-carbonyl chroman derivatives with high yield and is compatible with a wide variety of substituents. Synthetic applications of the 4-carbonyl chroman were also demonstrated.