Synthesis and unusual stability of pyridine and n??methyl pyridinium 1, 3??dioxolanes

ST Hobson, JD Boecker, JH Gifford…

Index: Hobson, Stephen T.; Boecker, Joseph D.; Gifford, James H.; Nohe, Tara L.; Wierks, Carl H. Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 2 p. 277 - 282

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Citation Number: 3

Abstract

Abstract Differentially substituted bridged pyridinium oximes are necessary in research on antidotes for organophosphate poisoning. A solid-phase synthesis would improve the yield and ease of purification of these compounds. To predict the lability of the linker in the final step of our proposed synthesis, we synthesized a series of pyridine and N-methyl pyridinium acetals. These compounds proved to be resistant to acid catalyzed hydrolysis. This ...