Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands

X Zhang, X Li, GF Allan, A Musto, SG Lundeen…

Index: Zhang, Xuqing; Li, Xiaojie; Allan, George F.; Musto, Amy; Lundeen, Scott G.; Sui, Zhihua Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3233 - 3237

Full Text: HTML

Citation Number: 21

Abstract

A novel series of tetracyclic indoles have been designed, synthesized and evaluated as androgen receptor (AR) ligands. Studies of structure–activity relationships (SARs) were investigated, which led to some compounds in this series as strong binders to androgen receptors.