General Route to Phosphonodithioic Acid Derivatives

…, AS Wagman, GG Zipp, MK Gratchev

Index: Martin; Wagman; Zipp; Gratchev Journal of Organic Chemistry, 1994 , vol. 59, # 26 p. 7957 - 7958

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Citation Number: 11

Abstract

Phosphonate derivatives are frequently used as re- placements of the phosphate moiety of biologically active mo1ecules.l Substitution of a methylene or difluorometh- ylene group for one of the bridging oxygen atoms of a phosphate provides a nonhydrolyzable analogue of a phosphoester linkage.2 Phosphonate derivatives have recently been exploited as inhibitors of proteases and esterase^,^ mechanistic probes of PLAz,4 and haptens for the production of catalytic ...