Synthesis of new heterocondensed pteridines

…, Y Shibata, M Morita, K Kaya, K Hiratani

Index: Chowdhury; Shibata; Morita; Kaya; Hiratani Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 5 p. 1173 - 1177

Full Text: HTML

Citation Number: 18

Abstract

Abstract Reaction of 2-aminopyrazine 1 with isothiocyanate, isocyanate or dithioketal reagent furnished pteridines 3, 4 in good yield. Thioxo compound 3a was chlorinated, methylated and subsequently displaced by amines. A simple one-step synthesis of heterocondensed pteridines 8–13 by reaction of 2-aminopyrazine with various imino thioacetals was described 8–13.