Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 1. 2-[2-(1-Imidazolyl) alkyl]-1 (2H)-phthalazinones

M Yamaguchi, K Kamei, T Koga, M Akima…

Index: Yamaguchi; Kamei; Koga; Akima; Kuroki; Ohi Journal of Medicinal Chemistry, 1993 , vol. 36, # 25 p. 4052 - 4060

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Citation Number: 94

Abstract

A number of 4-substituted 2-[o-(l-irnidazolyl) alkyl]-1 (2H)-phthalazinones were synthesized in order to develop agents possessing both thromboxane A2 synthetase inhibitory and bronchodilatory activities. The pharmacological evaluation of these compounds disclosed that they have both activities to various extents. Both activities were slightly dependent on the length of the 2-substituents and largely affected by the nature of the 4-substituents. ...