Advanced Synthesis & Catalysis

Synthesis of Selectively Mono??N??Arylated Aliphatic Diamines via Iridium??Catalyzed Amine Alkylation

B Blank, S Michlik, R Kempe

Index: Blank, Benoit; Michlik, Stefan; Kempe, Rhett Advanced Synthesis and Catalysis, 2009 , vol. 351, # 17 p. 2903 - 2911

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Citation Number: 71

Abstract

Abstract A highly selective phosphorus/nitrogen (P, N) ligand-based iridium catalyst system efficiently catalyzes the reaction of arylamines with unprotected amino alcohols, yielding N- arylated aliphatic diamines in yields of up to 93%. The reaction can be performed with a wide variety of branched and linear amino alcohols in combination with various aminopyridines or substituted anilines.