Folate antagonists. 21. Synthesis and antimalarial properties of 2, 4-diamino-6-(benzylamino) pyrido [3, 2-d] pyrimidines

NL Colbry, EF Elslager, LM Werbel

Index: Colbry, Norman L.; Elslager, Edward F.; Werbel, Leslie M. Journal of Medicinal Chemistry, 1985 , vol. 28, # 2 p. 248 - 252

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Citation Number: 6

Abstract

CH2C12. It was allowed to warm to room temperature and stirred overnight. The mixture wm treated with 50 mL of MeOH, stirred for 1 h, evaporated, treated again, and evaporated to dryness. This residue was taken up in a minimum volume of hot MeOH, treated with EtOAC, and allowed to crystallize to give 1.39 g (75%) of white crystals, mp 189-189.5 "C. Anal. (Cl0HIBN2O3S) C, H, N. ... Registry No. 1, 10463-20-4; 2, 70382-04-6; 3, 93565-13-0; 4, ...