Imino 1, 2, 3, 4-tetrahydrocyclopent [b] indole carbamates as dual inhibitors of acetylcholinesterase and monoamine oxidase

…, MC Merriman, GE Olsen, W Petko, GJ O'Malley

Index: Fink, David M.; Palermo; Bores, Gina M.; Huger, Francis P.; Kurys, Barbara E.; Merriman, Michael C.; Olsen, Gordon E.; Petko, Wayne; O'Malley, Gerard J. Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 6 p. 625 - 630

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Citation Number: 41

Abstract

A series of imino 1, 2, 3, 4-tetrahydrocyclopent [b] indole carbamates was prepared and evaluated as dual acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitors. Halogen substitution ortho to the carbamate functionality in the eight position resulted in a significant increase in binding affinity for both AChE and MAO-A.

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