Aryl ethynyl anthraquinones: A useful platform for targeting telomeric G-quadruplex structures

…, G Costa, ML Perrore, S Alcaro, M Freccero

Index: Percivalle, Claudia; Sissi, Claudia; Greco, Maria Laura; Musetti, Caterina; Mariani, Angelica; Artese, Anna; Costa, Giosue; Perrore, Maria Lucia; Alcaro, Stefano; Freccero, Mauro Organic and Biomolecular Chemistry, 2014 , vol. 12, # 22 p. 3744 - 3754

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Citation Number: 13

Abstract

Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest assay and molecular docking. Both the binding properties and G- quadruplex vs. duplex selectivity are controlled by the structures of the aryl ethynyl moieties.