An Efficient Synthesis of 3, 5-bis (2-Cyanoisopropyl) toluene

YH Mei, Y Luo, W Lu

Index: Mei, Yu-Hua; Luo, Yu; Lu, Wei Organic Preparations and Procedures International, 2008 , vol. 40, # 5 p. 487 - 489

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Abstract

Institute of Medicinal Chemistry, Department of Chemistry, East China Normal University, Shanghai 200062, PR CHlNA e-mail: wlu@ chem. emu. edu. cn 3, 5-bis (2-Cyanoisopropyl) toiuene (4) is a key intermediate for the preparation of anastrozole, an anti-tumor drug for the treatment of breast cancer. So far, the only synthetic route to 4 involves three steps from mesitylene (Scheme l). I* However, this patented approach suffers from low yield, ...