Synthesis and xanthine oxidase inhibitory analysis of 1H-pyrrolo [3, 2-c] pyridine-4, 6 (5H, 7H)-dione (3, 7-dideazaxanthine) and two of its derivatives

…, LB MacCartney, DA Hessinger

Index: Schneller; Hosmane; MacCartney; Hessinger Journal of Medicinal Chemistry, 1978 , vol. 21, # 9 p. 990 - 993

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Citation Number: 8

Abstract

(13). To a solution of 12 (0.3 g, 0.78 mmol) in MeOH (20 mL) solid NaBH,(0.1 g, 2.6 mmol) was added portionwise at 0" C. After 1 h the mixture was diluted with water and extracted with Et, O. Usual workup gave 13 (0.25 g) as an oil after chromatographic purification on silica gel (eluent: petroleum ether-Et20, 3: l)(83%): IR (CHC13) 3480, 3400-3350, 1730, 1610 cm-'; NMR 4.1-4.5 (br, 1 H, CHOH), 5.95 (dd, 1 H, J= 16 Hz, J= 7 Hz, 8.60 ppm (br, 1 ...