New Synthetic Methodology toward Macrolides/Macrolactams via Palladium-Catalyzed Carbon-Heteroatom Bond-Forming Reactions

T Sengoku, T Hamamatsu, T Inuzuka, M Takahashi…

Index: Sengoku, Tetsuya; Hamamatsu, Tomoya; Inuzuka, Toshiyasu; Takahashi, Masaki; Yoda, Hidemi Synlett, 2011 , # 12 p. 1766 - 1768

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Abstract

Abstract A concise and versatile syntheses of 11-16-membered macrolides and 13-15- membered macrolactams have been achieved using a Tsuji-Trost type reaction. This approach is composed of intramolecular cyclization employing ethyl carbonate with carboxylic acids and catalytic amount of Pd (PPh 3) 4 to form carbon-heteroatom covalent bonds with no use of stoichiometric reagents.