Steroids

Estrano [17, 16-e] pyrimidine-peptide conjugates

T Matsumoto, M Watanabe, S Mataka, T Thiemann

Index: Matsumoto, Tomohiro; Watanabe, Masataka; Mataka, Shuntaro; Thiemann, Thies Steroids, 2003 , vol. 68, # 9 p. 751 - 757

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Citation Number: 18

Abstract

The preparation of a steroidal heterocycle linked to the tripeptide Cys-Gly-Cys is described. Initially, an estrane-derived steroidal heterocycle containing an aminopyrimidine ring fused to the 16, 17-position of the steroidal nucleus was synthesized. Thereafter, protected amino acids were coupled iteratively by the DCC method, commencing at the amino group of the aminopyrimidine unit.