One-pot synthesis of N-substituted 2-methyl-4, 5, 6, 7-tetrahydroindole derivatives

C Tanyeli, İM Akhmedov, EY Yazıcıoğlu

Index: Tanyeli, Cihangir; Akhmedov, Idris M.; Yazicioglu, Emre Y. Tetrahedron Letters, 2004 , vol. 45, # 52 p. 9627 - 9629

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Citation Number: 6

Abstract

We describe the preliminary results of one-pot syntheses of various N-substituted 2-methyl- 4, 5, 6, 7-tetrahydroindole derivatives from 2-(2-bromoallyl) cyclohexanone and the corresponding primary amines in good yields. Aliphatic amines were directly converted to tetrahydroindoles, whereas aromatic amines needed an extra base treatment step to complete the transformation.