Archiv der Pharmazie

Cyclohex??1??ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5α Reductase

E Baston, OIA Salem, RW Hartmann

Index: Baston, Eckhard; Salem, Ola I. A.; Hartmann, Rolf W. Archiv der Pharmazie, 2003 , vol. 336, # 1 p. 31 - 38

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Citation Number: 13

Abstract

Abstract In search of novel nonsteroidal mimics of steroidal inhibitors of 5α reductase, 4-(2- phenylethyl) cyclohex-1-ene carboxylic acids 1—5 were synthesized with different substituents in para position of the phenyl ring (1: N, N-diisopropylcarbamoyl, 2: phenyl, 3: phenoxy, 4: benzoyl, and 5: benzyl). The principal synthetic approach for the desired compounds consisted of a Wittig olefination between 1, 4-dioxaspiro [4.5]-decane-8- ...