Chemical development of CI-1008, an enantiomerically pure anticonvulsant

MS Hoekstra, DM Sobieray, MA Schwindt…

Index: Hackbart,W.; Hartmann,M. Journal fuer Praktische Chemie (Leipzig), 1961 , vol. 14, # 1-2 p. 1 - 3

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Citation Number: 137

Abstract

... Select a Journal or Book Volume: Page: ... Prior to beginning our chemical development work the total quantity of CI-1008 prepared was about 50 g. The synthetic route (Scheme 1) used an asymmetric Evans alkylation 2 based on a chiral auxiliary prepared ...