The reaction of imidoesters with proteins and related small molecules
MJ Hunter, ML Ludwig
Index: Hunter,M.J.; Ludwig,M.L. Journal of the American Chemical Society, 1962 , vol. 84, p. 3491 - 3504
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Citation Number: 279
Abstract
The possible use of imidoesters as group specific reagents for the modification of protein amino groups was investigated. By the use of model compounds it was established that, of the reactive groups present in proteins, only the amino group reacted with imidoesters in aqueous solvents. Balance studies of the reaction between glycine and methyl benzimidate at pH 9.5 indicated that the amino group was converted to a single reaction product, the ...
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