On the microwave-assisted synthesis of acylphenothiazine derivatives-Experiment versus theory synergism
…, D Porumb, I Silaghi-Dumitrescu…
Index: Gaina, Luiza; Porumb, Dan; Silaghi-Dumitrescu, Ioan; Cristea, Castelia; Silaghi-Dumitrescu, Luminita Canadian Journal of Chemistry, 2010 , vol. 88, # 1 p. 42 - 49
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Citation Number: 12
Abstract
The microwave-assisted synthesis of a series of acylphenothiazine derivatives is described. 10 H-Phenothiazine-3-carbaldehyde derivatives were obtained in moderate yields by the Duff formylation reaction, and 10-acetyl-phenothiazine derivatives were obtained in excellent yields by acetylating phenothiazine derivatives with acetic anhydride. A theoretical explanation for the chemoselectivity and regioselectivity of these acylation reactions ...
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