A General and Facile Synthetic Approach to Nα-Boc Ureidoalanine Derivatives

H Teng, Y He, L Wu, J Su, X Feng, G Qiu, S Liang…

Index: Teng, Hanbing; He, Yunjiao; Wu, Lamei; Su, Jiangtao; Feng, Xichun; Qiu, Guofu; Liang, Shucai; Hu, Xianming Synlett, 2006 , # 6 p. 877 - 880

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Citation Number: 4

Abstract

Abstract We report a new and facile synthetic approach to N α-Boc ureidoalanine derivatives from commercially available Boc-l-aspartic acid. Not only N′-substituted but also N′, N′- disubstituted ureidoalanine derivatives may be obtained by this method. The key aspect of this method is the employment of a 5-oxazolidinone to provide proper protection of the α- nitrogen of l-aspartic acid. This ensures successful obtainment of the corresponding ...