Helvetica chimica acta

New Protected Protecting Groups for the 5′??Hydroxy Group of Deoxynucleosides by Use of 2??(Hydroxymethyl)??and 2??[(Methylamino) methyl] benzoyl Skeletons and …

K Seio, E Utagawa, M Sekine

Index: Seio, Kohji; Utagawa, Eri; Sekine, Mitsuo Helvetica Chimica Acta, 2004 , vol. 87, # 9 p. 2318 - 2333

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Citation Number: 5

Abstract

Abstract The new protecting groups 1a, b and 2a, b were developed for the 5′-OH group of deoxynucleosides by utilizing the unique characters of the sulfenate and sulfenamide linkage. These new protecting groups have a 2-(hydroxymethyl) benzoyl or 2-[(methylamino) methyl] benzoyl skeleton whose hydroxy O-atom or amino N-atom was blocked with a tritylthio-type substituent. They are removable by intramolecular cyclization following the ...