Tetrahedron

Total synthesis of pyridovericin

…, RM Adlington, A Conte, GJ Pritchard, R Marquez…

Index: Irlapati, Nageswara Rao; Adlington, Robert M.; Conte, Aurelia; Pritchard, Gareth J.; Marquez, Rodolfo; Baldwin, Jack E. Tetrahedron, 2004 , vol. 60, # 41 p. 9307 - 9317

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Citation Number: 18

Abstract

The total synthesis of the naturally occurring kinase inhibitor pyridovericin is reported. A flexible and efficient synthesis has been accomplished in good yield from readily available 2, 4-dihydroxypyridine. Pyridovericin is a key intermediate in our proposed biomimetic synthesis of pyridomacrolidin.