Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors

J Liang, A van Abbema, M Balazs…

Index: Journal of Medicinal Chemistry, , vol. 56, # 11 p. 4521 - 4536

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Citation Number: 26

Abstract

... Journal of Medicinal Chemistry. ... For those who do respond initially, loss of response occurs in 23–46% of patients annually, most often because of development of antidrug antibodies.(7) Therefore, significant unmet medical needs still exist for both psoriasis and IBD. ...