Tetrahedron

Pd (II)-catalyzed synthesis of indoles from α-aryloxime O-pentafluorobenzoates via intramolecular aromatic C–H amination

S Chiba, L Zhang, S Sanjaya, GY Ang

Index: Chiba, Shunsuke; Zhang, Line; Sanjaya, Stephen; Ang, Gim Yean Tetrahedron, 2010 , vol. 66, # 30 p. 5692 - 5700

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Citation Number: 19

Abstract

α-Aryl-α-aminocarbonyloxime O-pentafluorobenzoates are found to be promising precursors for synthesis of 2, 3-disubstituted indole derivatives catalyzed by PdCl2 (MeCN) 2 in the presence of MgO as a base. The reaction is supposed to proceed via intramolecular aromatic C–H amination of a vinyl nitrene–palladium intermediate.