Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure–activity relationship, structural biology, and cellular activity

P Innocenti, KMJ Cheung, S Solanki…

Index: Journal of Medicinal Chemistry, , vol. 55, # 7 p. 3228 - 3241

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Citation Number: 34

Abstract

... Journal of Medicinal Chemistry. ... Boronic esters 8 and 13 were formed using standard palladium chemistry(8) and subsequently coupled with 5-bromo-3-iodopyridin-2-amine under Suzuki conditions to afford bromopyridines 14.(10). ...

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