Benzodiazepine receptor binding and anticonflict activity in a series of 3, 6-disubstituted pyridazino [4, 3-c] isoquinolines devoid of anticonvulsant properties

E Toja, G Tarzia, D Barone, F Luzzani…

Index: Toja; Tarzia; Barone; Luzzani; Gallico Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1314 - 1319

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Citation Number: 9

Abstract

A series of 3, 6-disubstituted pyridazino [4, 3-c] isoquinolines were synthesized and tested for their ability to inhibit the binding of [3H] diazepam to rat brain receptors in vitro. Compounds bearing a phenyl, 4-methoxyphenyl, or methyl group at position 3 and a dialkylamino group at position 6 showed the highest affinity in the binding assay and were subsequently evaluated for their anticonflict and anticonvulsant effects. All of these ...