Synthesis and structure–activity relationship of a novel class of 15-membered macrolide antibiotics known as '11a-azalides'

T Sugimoto, T Tanikawa, K Suzuki…

Index: Sugimoto, Tomohiro; Tanikawa, Tetsuya; Suzuki, Keiko; Yamasaki, Yukiko Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5787 - 5801

Full Text: HTML

Citation Number: 7

Abstract

Macrolide antibiotics are widely prescribed for the treatment of respiratory tract infections; however, the increasing prevalence of macrolide-resistant pathogens is a public health concern. Therefore, the development of new macrolide scaffolds with activities against resistant pathogens is urgently needed. An efficient method for reconstructing the erythromycin A macrolactone skeleton has been established. Based on this methodology, ...

Related Articles:

Enzyme assisted preparation of enantiomerically pure β-adrenergic blockers II. Building blocks of high optical purity and their synthetic conversion

[Ader, Ulrich; Schneider, Manfred P. Tetrahedron: Asymmetry, 1992 , vol. 3, # 2 p. 205 - 208]

Enzyme assisted preparation of enantiomerically pure β-adrenergic blockers II. Building blocks of high optical purity and their synthetic conversion

[Ader, Ulrich; Schneider, Manfred P. Tetrahedron: Asymmetry, 1992 , vol. 3, # 2 p. 205 - 208]

Enzyme assisted preparation of enantiomerically pure β-adrenergic blockers II. Building blocks of high optical purity and their synthetic conversion

[Ader, Ulrich; Schneider, Manfred P. Tetrahedron: Asymmetry, 1992 , vol. 3, # 2 p. 205 - 208]

More Articles...